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Research

The main scientific activity of the Tissue Engineering Laboratory is located in the field of bone and cartilage tissue engineering. Our work includes basic research on in vitro biocompatibility of candidate biomaterials - potential scaffolds for tissue engineered products (TEPs) - as well as advanced techniques of in vitro tissue regeneration for reconstructive surgery of skeletal tissues.

Our team is currently exploring the area of mesenchymal stem cell biology, working on development of isolation, culturing and differentiation techniques of stem cells derived from tissues of human and animal origin.

We perform research on adipose tissue-derived mesenchymal cells differentiation mechanisms. Isolated and stimulated cells are characterized using state-of-the-art molecular and cell biology techniques, including Real-Time PCR, ELISA, FACS and fluorescence microscopy.

We also evaluate the effect of substrate stiffness on cell differentiation. Using custom-made substrates and in vitro cell cultures, we examine the viability and osteogenic potential of adherent cells.

Cell interaction in co-cultures is also examined in our laboratory. Co-cultures of osteoblasts, osteoclasts, endothelial cells and stem cells are performed in vitro to verify cell metabolism and phenotype.

Our team is involved in scientific projects, co-founded by EU as well as national grants, co-working with groups from various research areas, including materials science, chemical engineering and solid-state physics, .

Currently lead projects:

  1. Bio-implants for the Treatment of Bone Tissue Defects in Oncology Patients” - http://www.dotacjenasukces.eu/projekt/bioimplanty-dla-potrzeb-leczenia-ubytkow-tkanki-kostnej-u-chorych-onkologicznych/szczegoly/

  2. New, multifunctional bone substitutes with high surgical handiness"- http://www.ceramika.agh.edu.pl/projekt/

  3. "The development of innovative methods for the regeneration of bone defects using biovital, reasorbable implants seeded by autologous cells - for use in dental surgery" - http://www.ncbir.pl/en/